Journal article
Tricalcium phosphate based resorbable ceramics: Influence of NaF and CaO addition
Materials Science & Engineering C, Vol.28(1), pp.11-17
2008
Handle:
https://hdl.handle.net/2376/112588
Abstract
Resorbable bioceramics have gained much attention due to their time-varying mechanical properties
in-vivo. Implanted ceramics degrade allowing bone in-growth and eventual replacement of the artificial material with natural tissue. Calcium phosphate based materials have caught the most significant attention because of their excellent biocompatibility and compositional similarities to natural bone. Doping these ceramics with various metal ions has significantly influenced their properties. In this study, tricalcium phosphate (TCP) compacts were fabricated via uniaxial compression with five compositions: (i) pure TCP, (ii) TCP with 2.0 wt.% NaF, (iii) TCP with 3.0 wt.% CaO, (iv) TCP with a binary of 2.0 wt.% NaF and 0.5 wt.% Ag
2O, and (v) TCP with a quaternary of 1.0 wt.% TiO
2, 0.5 wt.% Ag
2O, 2.0 wt.% NaF, and 3.0 wt.% CaO. These compacts were sintered at 1250 °C for 4 h to obtain dense ceramic structures. Phase analyses were carried out using X-ray diffraction. The presence of NaF in TCP improved densification and increased compression strength from 70 (±
25) to 130 (±
40) MPa. Addition of CaO had no influence on density or strength. Human osteoblast cell growth behavior was studied using an osteoprecursor cell line (OPC 1) to assure that the biocompatibility of these ceramics was not altered due to the dopants. For long-term biodegradation studies, density, weight change, surface microstructure, and uniaxial compression strength were measured as a function of time in a simulated body fluid (SBF). Weight gain in SBF correlated strongly with precipitation viewed in the inter-connected pores of the samples. After 3 months in SBF, all samples displayed a reduction in strength. NaF, CaO and the quaternary compositions maintained the most steady strength loss under SBF.
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Details
- Title
- Tricalcium phosphate based resorbable ceramics: Influence of NaF and CaO addition
- Creators
- Zachary SeeleyAmit BandyopadhyaySusmita Bose
- Publication Details
- Materials Science & Engineering C, Vol.28(1), pp.11-17
- Academic Unit
- Mechanical and Materials Engineering, School of
- Publisher
- Elsevier B.V
- Identifiers
- 99900547784101842
- Language
- English
- Resource Type
- Journal article