Journal article
Tuberculosis Immunity: Opportunities from Studies with Cattle
Clinical & developmental immunology, Vol.2011, pp.768542-11
2011
Handle:
https://hdl.handle.net/2376/117123
PMCID: PMC3004413
PMID: 21197095
Abstract
Mycobacterium tuberculosis
and
M. bovis
share >99% genetic identity and induce similar host responses and disease profiles upon infection. There is a rich history of codiscovery in the development of control measures applicable to both human and bovine tuberculosis (TB) including skin-testing procedures,
M. bovis
BCG vaccination, and interferon-
γ
release assays. The calf TB infection model offers several opportunities to further our understanding of TB immunopathogenesis. Recent observations include correlation of central memory immune responses with TB vaccine efficacy, association of SIRP
α
+
cells in ESAT-6:CFP10-elicited multinucleate giant cell formation, early
γδ
T cell responses to TB, antimycobacterial activity of memory CD4
+
T cells via granulysin production, association of specific antibody with antigen burden, and suppression of innate immune gene expression in infected animals. Partnerships teaming researchers with veterinary and medical perspectives will continue to provide mutual benefit to TB research in man and animals.
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Details
- Title
- Tuberculosis Immunity: Opportunities from Studies with Cattle
- Creators
- W. Ray Waters - National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Ames, IA 50010, USAMitchell V Palmer - National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Ames, IA 50010, USATyler C Thacker - National Animal Disease Center, Agricultural Research Service, US Department of Agriculture, Ames, IA 50010, USAWilliam C Davis - Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USASrinand Sreevatsan - Departments of Veterinary Population Medicine and Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USAPaul Coussens - Molecular Biology and Molecular Virology, Department of Animal Science, Michigan State University, East Lansing, MI 48824, USAKieran G Meade - Animal Bioscience Centre, Teagasc, Grange, BT55&GE Co. Meath, IrelandJayne C Hope - Livestock Diseases Programme, Institute for Animal Health, Compton, Near Newbury RG20 7NN, UKD. Mark Estes - Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-1070, USA
- Publication Details
- Clinical & developmental immunology, Vol.2011, pp.768542-11
- Academic Unit
- Veterinary Microbiology and Pathology, Department of
- Publisher
- Hindawi Publishing Corporation
- Identifiers
- 99900548077401842
- Language
- English
- Resource Type
- Journal article