Tumor necrosis factor alpha in sleep regulation

Matthew D Rockstrom; Liangyu Chen; Ping Taishi; Joseph T Nguyen; Cody M Gibbons; Sigrid C Veasey; James M Krueger

doi:10.1016/j.smrv.2017.10.005

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Tumor necrosis factor alpha in sleep regulation

Journal article

Open access

Peer reviewed

Tumor necrosis factor alpha in sleep regulation

Matthew D Rockstrom, Liangyu Chen, Ping Taishi, Joseph T Nguyen, Cody M Gibbons, Sigrid C Veasey and James M Krueger

Sleep medicine reviews, Vol.40, pp.69-78

08/2018

DOI: https://doi.org/10.1016/j.smrv.2017.10.005

Handle:

https://hdl.handle.net/2376/113730

PMCID: PMC5955790

PMID: 29153862

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https://doi.org/10.1016/j.smrv.2017.10.005View

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Abstract

Autoimmunity

Sleep regulation

Tumor necrosis factor alpha

Brain organization of sleep

Plasticity

Sleep function

This review details tumor necrosis factor alpha (TNF) biology and its role in sleep, and describes how TNF medications influence sleep/wake activity. Substantial evidence from healthy young animals indicates acute enhancement or inhibition of endogenous brain TNF respectively promotes and inhibits sleep. In contrast, the role of TNF in sleep in most human studies involves pathological conditions associated with chronic elevations of systemic TNF and disrupted sleep. Normalization of TNF levels in such patients improves sleep. A few studies involving normal healthy humans and their TNF levels and sleep are consistent with the animal studies but are necessarily more limited in scope. TNF can act on established sleep regulatory circuits to promote sleep and on the cortex within small networks, such as cortical columns, to induce sleep-like states. TNF affects multiple synaptic functions, e.g., its role in synaptic scaling is firmly established. The TNF-plasticity actions, like its role in sleep, can be local network events suggesting that sleep and plasticity share biochemical regulatory mechanisms and thus may be inseparable from each other. We conclude that TNF is involved in sleep regulation acting within an extensive tightly orchestrated biochemical network to niche-adapt sleep in health and disease.

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Title: Tumor necrosis factor alpha in sleep regulation
Creators: Matthew D Rockstrom - School of Medicine, University of Washington, Spokane, WA, USA
Liangyu Chen - Integrative Physiology and Neuroscience, Washington State University-Spokane, Spokane, WA, USA
Ping Taishi - Integrative Physiology and Neuroscience, Washington State University-Spokane, Spokane, WA, USA
Joseph T Nguyen - Integrative Physiology and Neuroscience, Washington State University-Spokane, Spokane, WA, USA
Cody M Gibbons - School of Medicine, University of Washington, Spokane, WA, USA
Sigrid C Veasey - Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
James M Krueger - Integrative Physiology and Neuroscience, Washington State University-Spokane, Spokane, WA, USA
Publication Details: Sleep medicine reviews, Vol.40, pp.69-78
Academic Unit: Integrative Physiology and Neuroscience, Department of
Publisher: Elsevier Ltd
Identifiers: 99900547900101842
Language: English
Resource Type: Journal article