Journal article
Tumor necrosis factor receptor fragment attenuates interferon-γ-induced non-REM sleep in rabbits
Journal of neuroimmunology, Vol.119(2), pp.192-198
2001
Handle:
https://hdl.handle.net/2376/106380
PMID: 11585621
Abstract
Although the somnogenic actions of interferon-α (IFNα) and IFNβ have been reported, the sleep effects of IFNγ remained unknown. Thus, we investigated the effects of intracerebroventricular injection of human IFNγ on sleep in rabbits. IFNγ dose-dependently increased nonrapid eye movement sleep (NREMS), electroencephalographic slow wave activity and brain temperature (Tbr). These effects were markedly attenuated after the heat treatment of IFNγ. IFNγ suppressed rapid eye movement sleep if given during the light period, but not if given at dark onset. Although a tumor necrosis factor receptor fragment did not affect any sleep parameters when given at dark onset, it significantly attenuated IFNγ-induced NREMS and Tbr. These data suggest that IFNγ may be involved in the sleep responses during infection. Further, IFNγ may have a synergistic interaction with intrinsic TNFα in the brain.
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Details
- Title
- Tumor necrosis factor receptor fragment attenuates interferon-γ-induced non-REM sleep in rabbits
- Creators
- Takeshi Kubota - Department of Veterinary, Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, P.O. Box 646520, Pullman, WA 99164-6520, USAJeannine A Majde - Office of Naval Research, 800 N Quincy Street, Arlington, VA 22217, USARichard A Brown - Department of Veterinary, Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, P.O. Box 646520, Pullman, WA 99164-6520, USAJames M Krueger - Department of Veterinary, Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, P.O. Box 646520, Pullman, WA 99164-6520, USA
- Publication Details
- Journal of neuroimmunology, Vol.119(2), pp.192-198
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900546891501842
- Language
- English
- Resource Type
- Journal article