UV-Induced DNA Damage and Mutagenesis in Chromatin

Peng Mao; John J Wyrick; Steven A Roberts; Michael J Smerdon

doi:10.1111/php.12646

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UV-Induced DNA Damage and Mutagenesis in Chromatin

Journal article

Open access

Peer reviewed

UV-Induced DNA Damage and Mutagenesis in Chromatin

Peng Mao, John J Wyrick, Steven A Roberts and Michael J Smerdon

Photochemistry and photobiology, Vol.93(1), pp.216-228

01/2017

DOI: https://doi.org/10.1111/php.12646

Handle:

https://hdl.handle.net/2376/116141

PMCID: PMC5315636

PMID: 27716995

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Abstract

UV radiation induces photolesions that distort the DNA double helix and, if not repaired, can cause severe biological consequences, including mutagenesis or cell death. In eukaryotes, both the formation and repair of UV damage occur in the context of chromatin, in which genomic DNA is packaged with histones into nucleosomes and higher order chromatin structures. Here, we review how chromatin impacts the formation of UV photoproducts in eukaryotic cells. We describe the initial discovery that nucleosomes and other DNA binding proteins induce characteristic "photofootprints" during the formation of UV photoproducts. We also describe recent progress in genomewide methods for mapping UV damage, which echoes early biochemical studies, and highlights the role of nucleosomes and transcription factors in UV damage formation and repair at unprecedented resolution. Finally, we discuss our current understanding of how the distribution and repair of UV-induced DNA damage influence mutagenesis in human skin cancers.

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Title: UV-Induced DNA Damage and Mutagenesis in Chromatin
Creators: Peng Mao - School of Molecular Biosciences, Washington State University, Pullman, WA
John J Wyrick - Center for Reproductive Biology, Washington State University, Pullman, WA
Steven A Roberts - School of Molecular Biosciences, Washington State University, Pullman, WA
Michael J Smerdon - School of Molecular Biosciences, Washington State University, Pullman, WA
Publication Details: Photochemistry and photobiology, Vol.93(1), pp.216-228
Academic Unit: Molecular Biosciences, School of
Publisher: United States
Grant note: R37 ES002614 / NIEHS NIH HHS R01 ES002614 / NIEHS NIH HHS R00 ES022633 / NIEHS NIH HHS
Identifiers: 99900547561301842
Language: English
Resource Type: Journal article