Journal article
Uncovering physiologic mechanisms of circadian rhythms and sleep/wake regulation through mathematical modeling
Journal of biological rhythms, Vol.22(3), pp.233-245
06/2007
Handle:
https://hdl.handle.net/2376/106043
PMID: 17517913
Abstract
Mathematical models of neurobehavioral function are useful both for understanding the underlying physiology and for predicting the effects of rest-activity-work schedules and interventions on neurobehavioral function. In a symposium titled "Modeling Human Neurobehavioral Performance I: Uncovering Physiologic Mechanisms" at the 2006 Society for Industrial and Applied Mathematics/Society for Mathematical Biology (SIAM/SMB) Conference on the Life Sciences, different approaches to modeling the physiology of human circadian rhythms, sleep, and neurobehavioral performance and their usefulness in understanding the underlying physiology were examined. The topics included key elements of the physiology that should be included in mathematical models, a computational model developed within a cognitive architecture that has begun to include the effects of extended wake on information-processing mechanisms that influence neurobehavioral function, how to deal with interindividual differences in the prediction of neurobehavioral function, the applications of systems biology and control theory to the study of circadian rhythms, and comparisons of these methods in approaching the overarching questions of the underlying physiology and mathematical models of circadian rhythms and neurobehavioral function. A unifying theme was that it is important to have strong collaborative ties between experimental investigators and mathematical modelers, both for the design and conduct of experiments and for continued development of the models.
Metrics
16 Record Views
Details
- Title
- Uncovering physiologic mechanisms of circadian rhythms and sleep/wake regulation through mathematical modeling
- Creators
- Richard E Kronauer - Division of Sleep Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, Division of Applied Sciences, Harvard University, Cambridge, MA 02115, USAGlenn GunzelmannHans P A Van DongenFrancis J Doyle, 3rdElizabeth B Klerman
- Publication Details
- Journal of biological rhythms, Vol.22(3), pp.233-245
- Academic Unit
- Medical Education and Clinical Science, Department of
- Publisher
- United States
- Grant note
- K02 HD045459-04 / NICHD NIH HHS K02 HD045459-02 / NICHD NIH HHS K02 HD045459-05 / NICHD NIH HHS K02 HD045459 / NICHD NIH HHS K02-HD045459 / NICHD NIH HHS K02 HD045459-03 / NICHD NIH HHS K02 HD045459-01 / NICHD NIH HHS GM078993 / NIGMS NIH HHS
- Identifiers
- 99900546879801842
- Language
- English
- Resource Type
- Journal article