Understanding In Vivo Response and Mechanical Property Variation in MgO, SrO and SiO2 doped β-TCP

Susmita Bose; Solaiman Tarafder; Shashwat S Banerjee; Neal M Davies; Amit Bandyopadhyay

doi:10.1016/j.bone.2011.03.685

Back

Understanding In Vivo Response and Mechanical Property Variation in MgO, SrO and SiO2 doped β-TCP

Journal article

Open access

Peer reviewed

Understanding In Vivo Response and Mechanical Property Variation in MgO, SrO and SiO2 doped β-TCP

Susmita Bose, Solaiman Tarafder, Shashwat S Banerjee, Neal M Davies and Amit Bandyopadhyay

Bone (New York, N.Y.), Vol.48(6), pp.1282-1290

06/01/2011

DOI: https://doi.org/10.1016/j.bone.2011.03.685

Handle:

https://hdl.handle.net/2376/102914

PMCID: PMC3109736

PMID: 21419884

Files and links (1)

url

https://doi.org/10.1016/j.bone.2011.03.685View

Published (Version of record) Open

Abstract

in vivo osteogenesis

doping

β-tricalcium phosphate

MgO-SrO-SiO2

in vitro degradation

The aim of this work is to evaluate the influence of MgO, SrO and SiO 2 doping on mechanical and biological properties of β-tricalcium phosphate (β-TCP) to achieve controlled resorption kinetics of β-TCP system for maxillofacial and spinal fusion application. We prepared dense TCP compacts of four different compositions, i) pure β-TCP, ii) β-TCP with 1.0 wt. % MgO + 1.0 wt. % SrO, iii) β-TCP with 1.0 wt. % SrO + 0.5 wt. % SiO 2 , and iv) β-TCP with 1.0 wt. % MgO + 1.0 wt. % SrO + 0.5 wt. % SiO 2 , by uniaxial pressing and sintering at 1250 °C. β phase stability is observed at 1250 °C sintering temperature due to MgO doping in β-TCP. In vitro mineralization in simulated body fluid (SBF) for 16 weeks shows excellent apatite growth on undoped and doped samples. Strength degradation of TCP samples in SBF is significantly influenced by both dopant chemistry and amount of dopant. Compressive strengths for all samples show degradation in SBF over the 16 week time period with varying degradation kinetics. MgO/SrO/SiO 2 doped sample shows no strength loss, while undoped TCP shows the maximum strength loss from 419 ±28 MPa to 158 ±28 MPa over the 16 week study. In case of MgO/SrO doped TCP, strength loss is slow and gradual. TCP doped with 1.0 wt. % MgO and 1.0 wt. % SrO shows excellent in vivo biocompatibility when tested in male Sprague-Dawley rats for 16 weeks. Histomorphology analysis reveals that MgO/SrO doped TCP promoted osteogenesis by excellent early stage bone remodeling as compared to undoped TCP.

Metrics

8 Record Views

Details

Title: Understanding In Vivo Response and Mechanical Property Variation in MgO, SrO and SiO2 doped β-TCP
Creators: Susmita Bose - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USA
Solaiman Tarafder - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USA
Shashwat S Banerjee - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USA
Neal M Davies - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA 99164-2920, USA
Amit Bandyopadhyay - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USA
Publication Details: Bone (New York, N.Y.), Vol.48(6), pp.1282-1290
Academic Unit: Mechanical and Materials Engineering, School of
Grant note: R01 EB007351-01A1 || EB / National Institute of Biomedical Imaging and Bioengineering : NIBIB
Identifiers: 99900546553201842
Language: English
Resource Type: Journal article