Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics

Susmita Bose; Gary Fielding; Solaiman Tarafder; Amit Bandyopadhyay

doi:10.1016/j.tibtech.2013.06.005

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Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics

Journal article

Open access

Peer reviewed

Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics

Susmita Bose, Gary Fielding, Solaiman Tarafder and Amit Bandyopadhyay

Trends in biotechnology (Regular ed.), Vol.31(10), pp.594-605

10/2013

DOI: https://doi.org/10.1016/j.tibtech.2013.06.005

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https://hdl.handle.net/2376/110498

PMID: 24012308

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Abstract

Neovascularization, Physiologic - physiology

Osteogenesis - physiology

Animals

Metals - chemistry

Biocompatible Materials - chemistry

Humans

Osteogenesis - drug effects

Bone and Bones - blood supply

Calcium Phosphates - chemistry

Ceramics

Bone Remodeling

Tissue Engineering

General trends in synthetic bone grafting materials are shifting towards approaches that can illicit osteoinductive properties. Pharmacologics and biologics have been used in combination with calcium phosphate (CaP) ceramics, however, they have recently become the target of scrutiny over safety. The importance of trace elements in natural bone health is well documented. Ions, for example, lithium, zinc, magnesium, manganese, silicon, strontium, etc., have been shown to increase osteogenesis and neovascularization. Incorporation of dopants (trace metal ions) into CaPs can provide a platform for safe and efficient delivery in clinical applications where increased bone healing is favorable. This review highlights the use of trace elements in CaP biomaterials, and offers an insight into the mechanisms of how metal ions can enhance both osteogenesis and angiogenesis.

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Title: Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics
Creators: Susmita Bose - W.M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USA. Electronic address: sbose@wsu.edu
Gary Fielding
Solaiman Tarafder
Amit Bandyopadhyay
Publication Details: Trends in biotechnology (Regular ed.), Vol.31(10), pp.594-605
Academic Unit: Mechanical and Materials Engineering, School of
Publisher: England
Grant note: R01 EB007351 / NIBIB NIH HHS R01-EB-007351 / NIBIB NIH HHS
Identifiers: 99900546914301842
Language: English
Resource Type: Journal article