Journal article
Understanding the influence of MgO and SrO binary doping on the mechanical and biological properties of β-TCP ceramics
Acta biomaterialia, Vol.6(10), pp.4167-4174
2010
Handle:
https://hdl.handle.net/2376/104355
PMID: 20493283
Abstract
The objective of this study was to evaluate the influence of MgO and SrO doping on the mechanical and biological properties of β-tricalcium phosphate (β-TCP). β-TCP was doped with two different binary compositions, 0.25 and 1.0
wt.% SrO along with 1.0
wt.% MgO. MgO and SrO doping increased the β phase stability at a sintering temperature of 1250
°C and marginally decreased the compressive strength of β-TCP. An
in vitro cell–material interaction study, using human fetal osteoblast cells (hFOB), indicated that doped β-TCP was non-toxic, and MgO/SrO dopants improved cell attachment and growth. β-TCP implants doped with 1.0
wt.% MgO and 1.0
wt.% SrO showed good
in vivo biocompatibility when tested in male Sprague–Dawley rats for 16
weeks. Histomorphology analysis indicated that MgO/SrO-doped β-TCP promoted more osteogenesis than pure β-TCP.
In vivo osteocalcin and type I collagen assay also revealed faster bone formation in rats with doped β-TCP implant compared to rats with pure β-TCP implant. Low Ca
2+ concentration in the urine of rats with doped β-TCP implant confirmed slower degradation of MgO/SrO-doped β-TCP than pure β-TCP.
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Details
- Title
- Understanding the influence of MgO and SrO binary doping on the mechanical and biological properties of β-TCP ceramics
- Creators
- Shashwat S Banerjee - W.M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USASolaiman Tarafder - W.M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USANeal M Davies - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman, WA 99164-2920, USAAmit Bandyopadhyay - W.M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USASusmita Bose - W.M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USA
- Publication Details
- Acta biomaterialia, Vol.6(10), pp.4167-4174
- Academic Unit
- Mechanical and Materials Engineering, School of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900546964301842
- Language
- English
- Resource Type
- Journal article