Journal article
Understanding virus–host dynamics following EIAV infection in SCID horses
Journal of theoretical biology, Vol.343, pp.1-8
02/21/2014
Handle:
https://hdl.handle.net/2376/106877
PMID: 24252283
Abstract
We develop a mathematical model for the interaction between two competing equine infectious anemia virus strains and neutralizing antibodies. We predict that elimination of one or both virus strains depends on the initial antibody levels, the strength of antibody mediated neutralization, and the persistence of antibody over time. We further show that the ability of a subdominant, neutralization resistant virus to dominate the infection transiently or permanently is dependent on the antibody-mediated neutralization effect. Finally, we determine conditions for persistence of both virus strains. We fit our models to virus titers from horses (foals) with severe combined immunodeficiency to estimate virus–host parameters and to validate analytical results.
•We develop mathematical models of competition between two EIAV virus strains in SCID horses.•We examine the effect of infused antibody on viral dynamics.•We determine the conditions for virus elimination, one virus escape and coexistence.•We determine the differences in dynamics when the antibody levels are constant and decaying over time.
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Details
- Title
- Understanding virus–host dynamics following EIAV infection in SCID horses
- Creators
- Stanca M Ciupe - Department of Mathematics, Virginia Tech, Blacksburg, VA 24060, United StatesElissa J Schwartz - School of Biological Sciences and Department of Mathematics, Washington State University, Pullman, WA 99164, United States
- Publication Details
- Journal of theoretical biology, Vol.343, pp.1-8
- Academic Unit
- Biological Sciences, School of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900546997601842
- Language
- English
- Resource Type
- Journal article