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CC BY V4.0, Open Access
Journal article
Unique features of a global human ectoparasite identified through sequencing of the bed bug genome
Nature communications, Vol.7(1), pp.10165-10165
02/02/2016
Handle:
https://hdl.handle.net/2376/114901
PMCID: PMC4740739
PMID: 26836814
Abstract
The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of the C. lectularius sequenced genome (650 Mb) and 14,220 predicted protein-coding genes provide a comprehensive representation of genes that are linked to traumatic insemination, a reduced chemosensory repertoire of genes related to obligate hematophagy, host-symbiont interactions, and several mechanisms of insecticide resistance. In addition, we document the presence of multiple putative lateral gene transfer events. Genome sequencing and annotation establish a solid foundation for future research on mechanisms of insecticide resistance, human-bed bug and symbiont-bed bug associations, and unique features of bed bug biology that contribute to the unprecedented success of C. lectularius as a human ectoparasite.
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Details
- Title
- Unique features of a global human ectoparasite identified through sequencing of the bed bug genome
- Creators
- Joshua B Benoit - Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USAZach N Adelman - Fralin Life Science Institute and Department of Entomology, Virginia Tech, Blacksburg, Virginia 24061, USAKlaus Reinhardt - Department of Biology, Applied Zoology, Technische Universitaet Dresden, Dresden 01062, GermanyAmanda Dolan - Department of Biology, University of Rochester, Rochester, New York 14627, USAMonica Poelchau - National Agricultural Library, Beltsville, Maryland 20705, USAEmily C Jennings - Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USAElise M Szuter - Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USARichard W Hagan - Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USAHemant Gujar - Department of Entomology, University of Kentucky, Lexington, Kentucky 40546, USAJayendra Nath Shukla - Department of Entomology, University of Kentucky, Lexington, Kentucky 40546, USAFang Zhu - Department of Entomology, Washington State University, Pullman, Washington 99164, USAM Mohan - ICAR-National Bureau of Agricultural Insect Resources, Indian Council of Agricultural Research, Bengaluru 560024, IndiaDavid R Nelson - Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Sciences Center, Memphis, Tennessee 38163, USAAndrew J Rosendale - Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USAChristian Derst - Cologne Biocenter and Zoological Institute, University of Cologne, Cologne 50674, GermanyValentina Resnik - Institut für Bienenkunde (Polytechnische Gesellschaft), Goethe University Frankfurt, Oberursel 61440, GermanySebastian Wernig - Institut für Bienenkunde (Polytechnische Gesellschaft), Goethe University Frankfurt, Oberursel 61440, GermanyPamela Menegazzi - Department of Neurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Würzburg 97074, GermanyChristian Wegener - Department of Neurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Würzburg 97074, GermanyNicolai Peschel - Department of Neurobiology and Genetics, Theodor-Boveri-Institute, Biocenter, University of Würzburg, Würzburg 97074, GermanyJacob M Hendershot - Department of Biological Sciences, University of Cincinnati, Cincinnati, Ohio 45221, USAWolfgang Blenau - Cologne Biocenter and Zoological Institute, University of Cologne, Cologne 50674, GermanyReinhard Predel - Cologne Biocenter and Zoological Institute, University of Cologne, Cologne 50674, GermanyPaul R Johnston - Department of Evolutionary Biology, Institute of Biology, Freie Universitaet, Berlin 14195, GermanyPanagiotis Ioannidis - Department of Genetic Medicine and Development and Swiss Institute of Bioinformatics, University of Geneva, Geneva 1211, SwitzerlandRobert M Waterhouse - Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology and The Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USARalf Nauen - Pest Control Biology and Research Technologies, Bayer CropScience AG, Monheim 40789, GermanyCorinna Schorn - Pest Control Biology and Research Technologies, Bayer CropScience AG, Monheim 40789, GermanyMark-Christoph Ott - Pest Control Biology and Research Technologies, Bayer CropScience AG, Monheim 40789, GermanyFrank Maiwald - Pest Control Biology and Research Technologies, Bayer CropScience AG, Monheim 40789, GermanyJ Spencer Johnston - Department of Entomology, Texas A&M University, College Station, Texas 77843, USAAmeya D Gondhalekar - Department of Entomology, Purdue University, West Lafayette, Indiana 47907, USAMichael E Scharf - Department of Entomology, Purdue University, West Lafayette, Indiana 47907, USABrittany F Peterson - Department of Entomology, Purdue University, West Lafayette, Indiana 47907, USAKapil R Raje - Department of Entomology, Purdue University, West Lafayette, Indiana 47907, USABenjamin A Hottel - Department of Entomology and Nematology, University of Florida, Gainesville, Florida 32611, USADavid Armisén - Institue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, FranceAntonin Jean Johan Crumière - Institue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, FrancePeter Nagui Refki - Institue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, FranceMaria Emilia Santos - Institue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, FranceEssia Sghaier - Institue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, FranceSèverine Viala - Institue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, FranceAbderrahman Khila - Institue de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure de Lyon, UMR5242-CNRS, Lyon 69007, FranceSeung-Joon Ahn - Department of Entomology, Max Planck Institute for Chemical Ecology, Jena 07745, GermanyChristopher Childers - National Agricultural Library, Beltsville, Maryland 20705, USAChien-Yueh Lee - Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 10617, TaiwanHan Lin - Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 10617, TaiwanDaniel S T Hughes - Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USAElizabeth J Duncan - Department of Biochemistry and Genetics Otago, University of Otago, Dunedin 9054, New ZealandShwetha C Murali - Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USAJiaxin Qu - Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USAShannon Dugan - Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USASandra L Lee - Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USAHsu Chao - Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USAHuyen Dinh - Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USAYi Han - Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USAHarshavardhan Doddapaneni - Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USAKim C Worley - Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USADonna M Muzny - Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USADavid Wheeler - Institute of Fundamental Science, Massey University, Palmerston North 4442, New ZealandKristen A Panfilio - Institute for Developmental Biology, University of Cologne, Cologne 50674, GermanyIris M Vargas Jentzsch - Institute for Developmental Biology, University of Cologne, Cologne 50674, GermanyEdward L Vargo - Department of Entomology, Texas A&M University, College Station, Texas 77843, USAWarren Booth - Department of Biological Sciences, University of Tulsa, Tulsa, Oklahoma 74104, USAMarkus Friedrich - Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USAMatthew T Weirauch - Center for Autoimmune Genomics and Etiology, Division of Biomedical Informatics, and Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USAMichelle A E Anderson - Fralin Life Science Institute and Department of Entomology, Virginia Tech, Blacksburg, Virginia 24061, USAJeffery W Jones - Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USAOmprakash Mittapalli - Department of Entomology, The Ohio State University, Wooster, Ohio 44691, USAChaoyang Zhao - Department of Entomology, The Ohio State University, Wooster, Ohio 44691, USAJing-Jiang Zhou - Department of Biological Chemistry and Crop Protection, Rothamsted Research, BBSRC Harpenden, Herts AL5 2JQ, UKJay D Evans - United States Department of Agriculture-Agricultural Research Service Bee Research Laboratory, Beltsville, Maryland 20705, USAGeoffrey M Attardo - Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, Connecticut 06520, USAHugh M Robertson - Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USAEvgeny M Zdobnov - Department of Genetic Medicine and Development and Swiss Institute of Bioinformatics, University of Geneva, Geneva 1211, SwitzerlandJose M C Ribeiro - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, Bethesda, Maryland 20892, USARichard A Gibbs - Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USAJohn H Werren - Department of Biology, University of Rochester, Rochester, New York 14627, USASubba R Palli - Department of Entomology, University of Kentucky, Lexington, Kentucky 40546, USACoby Schal - Department of Entomology and W.M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695, USAStephen Richards - Human Genome Sequencing Center, Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
- Publication Details
- Nature communications, Vol.7(1), pp.10165-10165
- Academic Unit
- Department of Entomology
- Publisher
- Nature Publishing Group; England
- Grant note
- GM070559-9 / NIGMS NIH HHS 260986 / European Research Council UL1 TR001427 / NCATS NIH HHS U54 HG003273 / NHGRI NIH HHS 616346 / European Research Council R01 GM070559 / NIGMS NIH HHS
- Identifiers
- 99900547751701842
- Language
- English
- Resource Type
- Journal article