Journal article
Unprecedented peroxidase-mimicking activity of single-atom nanozyme with atomically dispersed Fe-N x moieties hosted by MOF derived porous carbon
Biosensors & bioelectronics, Vol.142, p.111495
10/01/2019
PMID: 31310943
Abstract
Due to robustness, easy large-scale preparation and low cost, nanomaterials with enzyme-like characteristics (defined as 'nanozymes') are attracting increasing interest for various applications. However, most of currently developed nanozymes show much lower activity in comparison with natural enzymes, and the deficiency greatly hinders their use in sensing and biomedicine. Single-atom catalysts (SACs) offer the unique feature of maximum atomic utilization, providing a potential pathway to improve the catalytic activity of nanozymes. Herein, we propose a Fe-N-C single-atom nanozyme (SAN) that exhibits unprecedented peroxidase-mimicking activity. The SAN consists of atomically dispersed Fe─N
moieties hosted by metal-organic frameworks (MOF) derived porous carbon. Thanks to the 100% single-atom active Fe dispersion and the large surface area of the porous support, the Fe-N-C SAN provided a specific activity of 57.76 U mg
, which was almost at the same level as natural horseradish peroxidase (HRP). Attractively, the SAN presented much better storage stability and robustness against harsh environments. As a proof-of-concept application, highly sensitive biosensing of butyrylcholinesterase (BChE) activity using the Fe-N-C SAN as a substitute for natural HRP was further verified.
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Details
- Title
- Unprecedented peroxidase-mimicking activity of single-atom nanozyme with atomically dispersed Fe-N x moieties hosted by MOF derived porous carbon
- Creators
- Xiangheng Niu - Washington State UniversityQiurong Shi - Washington State UniversityWenlei Zhu - Washington State UniversityDong Liu - Washington State UniversityHangyu Tian - Washington State UniversityShaofang Fu - Washington State UniversityNan Cheng - Washington State UniversitySuiqiong Li - Washington State UniversityJordan N Smith - Pacific Northwest National LaboratoryDan Du - Washington State UniversityYuehe Lin - Washington State University
- Publication Details
- Biosensors & bioelectronics, Vol.142, p.111495
- Academic Unit
- School of Mechanical and Materials Engineering
- Grant note
- R01OH011023 / ACL HHS R01 OH011023 / NIOSH CDC HHS
- Identifiers
- 99901227641101842
- Language
- English
- Resource Type
- Journal article