Journal article
Using ethyl glucuronide in urine to detect light and heavy drinking in alcohol dependent outpatients
Drug and alcohol dependence, Vol.157, pp.184-187
12/01/2015
Handle:
https://hdl.handle.net/2376/116375
PMCID: PMC4663163
PMID: 26475403
Abstract
This study investigated which ethyl glucuronide immunoassay (EtG-I) cutoff best detects heavy versus light drinking over five days in alcohol dependent outpatients.
A total of 121 adults with alcohol use disorders and co-occurring psychiatric disorders took part in an alcohol treatment study. Participants provided self-reported drinking data and urine samples three times per week for 16-weeks (total samples=2761). Agreement between low (100 ng/mL, 200 ng/mL), and moderate (500 ng/mL) EtG-I cutoffs and light (women ≤3 standard drinks, men ≤4 standard drinks) and heavy drinking (women >3, men >4 standard drinks) were calculated over one to five days.
The 100 ng/mL cutoff detected >76% of light drinking for two days, and 66% at five days. The 100 ng/mL cutoff detected 84% (1 day) to 79% (5 days) of heavy drinking. The 200 ng/mL cutoff detected >55% of light drinking across five days and >66% of heavy drinking across five days. A 500 ng/mL cutoff identified 68% of light drinking and 78% of heavy drinking for one day, with detection of light (2-5 days <58%) and heavy drinking (2-5 days <71%) decreasing thereafter. Relative to 100 ng/mL, the 200 ng/mL and 500 ng/mL cutoffs were less likely to result in false positives.
An EtG-I cutoff of 100 ng/mL is most likely to detect heavy drinking for up to five days and any drinking during the previous two days. Cutoffs of ≥500 ng/mL are likely to only detect heavy drinking during the previous day.
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Details
- Title
- Using ethyl glucuronide in urine to detect light and heavy drinking in alcohol dependent outpatients
- Creators
- Michael G McDonell - Initiative for Research and Education to Advance Community Health (I-REACH), Washington State University, Box 1495, Spokane, WA 99210, United States. Electronic address: mmcdonell@wsu.eduJordan Skalisky - Initiative for Research and Education to Advance Community Health (I-REACH), Washington State University, Box 1495, Spokane, WA 99210, United StatesEmily Leickly - Harborview Medical Center, Department of Psychiatry and Behavioral Sciences, University of Washington, Box 359911, 325 9th Avenue, Seattle, WA 98195, United StatesSterling McPherson - Program of Excellence in Addictions Research, Washington State University, PO Box 1495, Spokane, WA 99210 and Providence Medical Research Center, Providence Health Care, Spokane, WA 99210, United StatesSamuel Battalio - Harborview Medical Center, Department of Psychiatry and Behavioral Sciences, University of Washington, Box 359911, 325 9th Avenue, Seattle, WA 98195, United StatesJenny R Nepom - Initiative for Research and Education to Advance Community Health (I-REACH), Washington State University, Box 1495, Spokane, WA 99210, United StatesDebra Srebnik - Harborview Medical Center, Department of Psychiatry and Behavioral Sciences, University of Washington, Box 359911, 325 9th Avenue, Seattle, WA 98195, United StatesJohn Roll - Program of Excellence in Addictions Research, Washington State University, PO Box 1495, Spokane, WA 99210 and Providence Medical Research Center, Providence Health Care, Spokane, WA 99210, United StatesRichard K Ries - Harborview Medical Center, Department of Psychiatry and Behavioral Sciences, University of Washington, Box 359911, 325 9th Avenue, Seattle, WA 98195, United States
- Publication Details
- Drug and alcohol dependence, Vol.157, pp.184-187
- Academic Unit
- Elson S. Floyd College of Medicine; Medical Education and Clinical Science, Department of
- Publisher
- Ireland
- Grant note
- R01AA02024801A1 / NIAAA NIH HHS R01 AA020248 / NIAAA NIH HHS
- Identifiers
- 99900547409701842
- Language
- English
- Resource Type
- Journal article