Journal article
Uterine-conceptus interactions and reproductive failure in cattle
Theriogenology, Vol.56(9), pp.1435-1450
2001
Handle:
https://hdl.handle.net/2376/107989
PMID: 11768809
Abstract
The dialogue between trophectoderm cells of the conceptus and epithelial cells of the endometrium is critical to CL maintenance and embryo survival. The signal transduction mechanisms by which bovine interferon (IFN)-τ regulates cyclooxygenase (COX)-2 expression and secretion of prostaglandin F
2α (PGF
2α) in bovine endometrial (BEND) cells is examined. Stimulation of Protein Kinase C with a phorbol ester (phorbol 12, 13 dibutyrate [PDBu]) activates COX-2 gene expression and PGF
2α secretion via the mitogen-activated protein kinase (MAPK) pathway. Interferon-τ attenuates PDBu activation of PGF
2α secretion, but this inhibitory effect appears to be independent of the MAPK pathway. Embryonic IFN-τ, acting through a Type I IFN receptor, activates the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway resulting in activation or repression of interferon-stimulated genes. Experimental evidence is provided that IFN-τ regulation of STATs regulates gene expression of COX-2 in a manner that decreases secretion of PGF
2α. Maternal regulation of the antiluteolytic pathway is discussed relative to the ability of the polyunsaturated fatty acid, eicosapentaenoic (EPA), to decrease endometrial secretion of PGF
2α and progesterone to increase both conceptus development and IFN-τ secretion.
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Details
- Title
- Uterine-conceptus interactions and reproductive failure in cattle
- Creators
- W.W Thatcher - Department of Animal Sciences, University of Florida, Gainesville, Florida, 32610, USAA Guzeloglu - Department of Animal Sciences, University of Florida, Gainesville, Florida, 32610, USAR Mattos - Department of Animal Sciences, University of Florida, Gainesville, Florida, 32610, USAM Binelli - Centro de Biotecnologia em Reproducao Animal, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Pirassununga, SP 13630-000, BrazilT.R Hansen - Department of Animal Science, University of Wyoming, Laramie, Wyoming, 82071, USAJ.K Pru - Vincent Center for Reproductive Biology, Massachusetts General Hospital Boston, Massachusetts, USA
- Publication Details
- Theriogenology, Vol.56(9), pp.1435-1450
- Academic Unit
- Animal Sciences, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547396801842
- Language
- English
- Resource Type
- Journal article