Journal article
Utility of a sustained-release formulation for antihypertensive therapy
Journal of human hypertension, Vol.7(5), pp.519-522
10/1993
Handle:
https://hdl.handle.net/2376/114310
PMID: 8263896
Abstract
Recent pharmacotherapeutic advances in the treatment of hypertension have included the development of sustained-release (SR) dosage formulations, providing patients with the convenience of once daily administration. A one year retrospective analysis was undertaken to determine the economic utility of providing prescription coverage for the SR formulation of verapamil, a calcium channel antagonist, under the state of Florida's Medicaid programme. Data for this analysis were derived from the state of Florida's Medicaid computer archive. The study population consisted of 274 ambulatory beneficiaries diagnosed with hypertension and prescribed either the SR or immediate-release (IR) formulation of verapamil. Multivariate regression analysis was used to discern the incremental influence of selected demographic characteristics, utilisation of medical services prior to diagnosis for hypertension and prescribed formulation of verapamil on health care expenditures one year post-diagnosis. Patients prescribed the SR formulation of verapamil achieved a significant (P < or = 0.05) increase in the Medication Possession Ratio (MPR), an index of compliance, (0.87 +/- 0.13) relative to patients prescribed the IR formulation (0.56 +/- 0.10). Results indicate that receipt of verapamil in an SR formulation was associated with a significant (P < or = 0.05) decrease in aggregate health care expenditures of $110.14 over the one year study period. Receipt of the SR formulation was associated with an increase in expenditures for antihypertensive therapy ($117.83, p < or = 0.05) and a decrease in financial commitments for physician ($50.42, p < or = 0.05), hospital ($153.61, p < or = 0.05) and laboratory ($23.94, p < or = 0.05) services.
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Details
- Title
- Utility of a sustained-release formulation for antihypertensive therapy
- Creators
- T L Skaer - College of Pharmacy, Washington State University, Pullman 99164-6510D A SclarD J MarkowskiJ K Won
- Publication Details
- Journal of human hypertension, Vol.7(5), pp.519-522
- Academic Unit
- Pharmacotherapy, Department of
- Publisher
- England
- Identifiers
- 99900547816801842
- Language
- English
- Resource Type
- Journal article