Journal article
Vagotomy attenuates but does not prevent the somnogenic and febrile effects of lipopolysaccharide in rats
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.274(2), pp.R406-R411
02/01/1998
Handle:
https://hdl.handle.net/2376/102583
PMID: 9486298
Abstract
The role of the vagus nerve in the somnogenic and pyrogenic effects of lipopolysaccharide (LPS) was studied in rats. Control rats ( n= 8) and rats subjected to bilateral subdiaphragmal vagotomy (VX; n = 9) were injected with 100 μg/kg ip LPS at the beginning of the dark period. Sleep and brain temperature (Tbr) were recorded for 23 h after the injections. LPS caused increases in non-rapid eye movement sleep (NREMS) for 12 h after the injection in control rats. Sleep intensity, as indicated by the slow-wave activity (SWA) of the electroencephalogram during NREMS, was suppressed. LPS elicited biphasic Tbr responses: an initial hypothermia was followed by increases in Tbr that lasted for ∼20 h. In vagotomized rats, the NREMS responses to LPS were blunted. The magnitude of the LPS-induced NREMS increases was about one-half of that seen in control rats, and these sleep responses lasted only for 6 h. LPS did not affect SWA in VX animals. VX completely abolished the hypothermic responses to LPS and shortened the duration of the hyperthermia. The results suggest that the subdiaphragmal vagi play an important, but not exclusive, role in the somnogenic and pyrogenic actions of intraperitoneally injected LPS.
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Details
- Title
- Vagotomy attenuates but does not prevent the somnogenic and febrile effects of lipopolysaccharide in rats
- Creators
- Levente Kapás - Department of Physiology and Biophysics, University of Tennessee, Memphis, Tennessee 38163Michael K Hansen - Department of Physiology and Biophysics, University of Tennessee, Memphis, Tennessee 38163Hee-Yoon Chang - Department of Physiology and Biophysics, University of Tennessee, Memphis, Tennessee 38163James M Krueger - Department of Physiology and Biophysics, University of Tennessee, Memphis, Tennessee 38163
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.274(2), pp.R406-R411
- Academic Unit
- Biomedical Sciences, Department of; Integrative Physiology and Neuroscience, Department of
- Identifiers
- 99900546524401842
- Language
- English
- Resource Type
- Journal article