Journal article
Validation of Calibration Parameters for Trapped Ion Mobility Spectrometry
Journal of the American Society for Mass Spectrometry, Vol.30(10), pp.2152-2162
10/2019
Handle:
https://hdl.handle.net/2376/110489
PMID: 31392697
Abstract
Using contemporary theory for ion mobility spectrometry (IMS), gas-phase ion mobilities within a trapped ion mobility-mass spectrometer (TIMS) are not easily deduced using first principle equations due to non-linear pressure changes and consequently variations in E/N. It is for this reason that prior literature values have traditionally been used for TIMS calibration. Additionally, given that verified mobility standards currently do not exist and the that the exact conditions used to measure reported literature values may not always represent the environment within the TIMS, a direct approach to validating the behavior of the TIMS system is warranted. A calibration procedure is presented where an ambient pressure, ambient temperature, two-gate, printed circuit board drift-tube IMS (PCBIMS) is coupled to the front of a TIMS allowing reduced mobilities to be directly measured on the same instrument as the TIMS. These measured mobilities were used to evaluate the TIMS calibration procedure which correlates reduced mobility and TIMS elution voltages with literature values. When using the measured PCBIMS-reduced mobilities of tetraalkyl ammonium salts and tune mix for TIMS calibration of the alkyltrimethyl ammonium salts, the percent error is less than 1% as compared with using the reported literature K
values where the percent error approaches 5%. This method provides a way to obtain accurate reference mobilities for ion mobility techniques that require a calibration step (i.e., TIMS and TWAVE).
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Details
- Title
- Validation of Calibration Parameters for Trapped Ion Mobility Spectrometry
- Creators
- Cameron N Naylor - Department of Chemistry, Washington State University, Pullman, WA, 99164, USATobias Reinecke - Department of Chemistry, Washington State University, Pullman, WA, 99164, USAMark E Ridgeway - Bruker Daltonics Inc., Billerica, MA, 01821, USAMelvin A Park - Bruker Daltonics Inc., Billerica, MA, 01821, USABrian H Clowers - Department of Chemistry, Washington State University, Pullman, WA, 99164, USA. brian.clowers@wsu.edu
- Publication Details
- Journal of the American Society for Mass Spectrometry, Vol.30(10), pp.2152-2162
- Academic Unit
- Chemistry, Department of
- Publisher
- United States
- Grant note
- HDTRA1-14-1-0023 / Defense Threat Reduction Agency CHE-1506672 / Division of Chemistry
- Identifiers
- 99900547699101842
- Language
- English
- Resource Type
- Journal article