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CC BY V4.0, Open Access
Journal article
Vinclozolin induced epigenetic transgenerational inheritance of pathologies and sperm epimutation biomarkers for specific diseases
PloS one, Vol.13(8), pp.e0202662-e0202662
2018
Handle:
https://hdl.handle.net/2376/115678
PMID: 30157260
Abstract
Exposure to vinclozolin has been shown to induce the epigenetic transgenerational inheritance of increased susceptibility to disease, and to induce transgenerational changes to the epigenome. In the current study, gestating F0 generation rats were exposed to vinclozolin, and the subsequent F1, F2 and transgenerational F3 generations were evaluated for diseases and pathologies. F1 and F2 generation rats exhibited few abnormalities. However, F3 generation rats showed transgenerational increases in testis, prostate, and kidney disease, changes in the age of puberty onset in males, and an increased obesity rate in females. Overall there was an increase in the rate of animals with disease, and in the incidence of animals with multiple diseases. The objective of the current study was to analyze the sperm epigenome of F3 generation rats with specific abnormalities and compare them to rats without those abnormalities, in an effort to find epigenetic biomarkers of transgenerational disease. Unique signatures of differential DNA methylation regions (DMRs) in sperm were found that associated with testis disease, prostate disease and kidney disease. Confounding factors identified were the presence of multiple diseases in the analysis and the limited number of animals without disease. These results further our understanding of the mechanisms governing epigenetic transgenerational inheritance, and may lead in the future to the use of epigenetic biomarkers that will help predict an individual's susceptibility for specific diseases.
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Details
- Title
- Vinclozolin induced epigenetic transgenerational inheritance of pathologies and sperm epimutation biomarkers for specific diseases
- Creators
- Eric Nilsson - Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, United States of AmericaStephanie E King - Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, United States of AmericaMargaux McBirney - Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, United States of AmericaDeepika Kubsad - Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, United States of AmericaMichelle Pappalardo - Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, United States of AmericaDaniel Beck - Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, United States of AmericaIngrid Sadler-Riggleman - Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, United States of AmericaMichael K Skinner - Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, United States of America
- Publication Details
- PloS one, Vol.13(8), pp.e0202662-e0202662
- Academic Unit
- Biological Sciences, School of
- Publisher
- United States
- Identifiers
- 99900547864301842
- Language
- English
- Resource Type
- Journal article