Vitamin E and alpha-lipoic acid supplementation increase bleeding tendency via an intrinsic coagulation pathway

Susan A Marsh; Jeff S Coombes

doi:10.1177/107602960601200204

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Vitamin E and alpha-lipoic acid supplementation increase bleeding tendency via an intrinsic coagulation pathway

Journal article

Open access

Vitamin E and alpha-lipoic acid supplementation increase bleeding tendency via an intrinsic coagulation pathway

Susan A Marsh and Jeff S Coombes

Clinical and applied thrombosis/hemostasis, Vol.12(2), pp.169-173

04/2006

DOI: https://doi.org/10.1177/107602960601200204

Handle:

https://hdl.handle.net/2376/113603

PMID: 16708118

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Abstract

Prothrombin Time

Rats

Vitamin E - blood

Male

Thioctic Acid - pharmacology

Antioxidants - pharmacology

Animals

Blood Coagulation - drug effects

Partial Thromboplastin Time

Malondialdehyde - blood

Lipid Peroxidation - drug effects

Hemorrhage - chemically induced

Drug Therapy, Combination

Dietary Supplements

Vitamin E - pharmacology

Vitamin E and alpha-lipoic acid are potent nutritional antioxidants, and when used together, their antioxidant capabilities are improved as alpha-lipoic acid recycles vitamin E. Supplementation of vitamin E has been shown to prolong platelet aggregation but the effects of vitamin E and alpha-lipoic acid supplementation on bleeding tendency have yet to be reported. Young, male rats consumed either control diet (n=5) or vitamin E and alpha-lipoic acid-supplemented diet (n=5) for 14 weeks. Activated partial thromboplastin time (APTT) and prothrombin time (PT) were measured as markers of intrinsic and extrinsic coagulation pathways respectively in addition to lipid peroxidation (malondialdehyde). Supplementation significantly prolonged APTT (23.8+/-1.5 vs 31.4+/-1.2s, p<0.05) compared to the control diet; however, there was no significant difference in PT (27.8+/-1.5 vs 26.6+/-0.9s, p>0.05). While vitamin E was increased (p<0.05), there was no significant difference in plasma levels of malondialdehyde (p>0.05). Dietary supplementation of vitamin E and alpha-lipoic acid increases bleeding tendency via inhibition of the intrinsic coagulation pathway with no change in markers of lipid peroxidation. Such supplementation could benefit patients with cardiovascular disease who exhibit elevated levels of coagulation and oxidative stress.

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Title: Vitamin E and alpha-lipoic acid supplementation increase bleeding tendency via an intrinsic coagulation pathway
Creators: Susan A Marsh - School of Human Movement Studies, The University of Queensland, Brisbane, Australia
Jeff S Coombes
Publication Details: Clinical and applied thrombosis/hemostasis, Vol.12(2), pp.169-173
Academic Unit: Pharmaceutical Sciences, Department of
Publisher: United States
Identifiers: 99900547337901842
Language: English
Resource Type: Journal article