Journal article
Waveform parameters of retrobulbar vessels in glaucoma patients with different demographics and disease severity
European journal of ophthalmology, Vol.30(5), pp.1120672119848259-1027
05/07/2019
Handle:
https://hdl.handle.net/2376/116371
PMID: 31064210
Abstract
To identify novel velocity waveform parameters of the ophthalmic artery and central retinal artery by computer-aided image processing of Doppler ultrasonography measurements, and to evaluate correlations between the waveform parameters and different demographics and disease severity of open-angle glaucoma patients.
Thirty-six images of 36 open-angle glaucoma patients were considered. A semiautomated image processing code was used to detect the digitalized ophthalmic artery and central retinal artery velocity waveforms and to extract the waveform parameters. Concordance correlation coefficient, two-sample t-test, and Pearson's correlation coefficient were used to test for similarities, differences, and associations among variables.
Female glaucoma patients showed a statistically higher ophthalmic artery normalized distance between ascending and descending limb (p = 0.004), hypertensive glaucoma patients a statistically higher ophthalmic artery peak systolic velocity time (p = 0.025), glaucoma patients with hyperlipidemia a statistically higher ophthalmic artery resistivity index (p = 0.023) and a statistically higher ophthalmic artery peak systolic velocity acceleration (p = 0.025), glaucoma patients with cardiovascular diseases a statistically lower central retinal artery normalized distance between ascending and descending limb of the wave (p = 0.033) and a statistically higher central retinal artery period (p = 0.028), and patients with different body mass index a statistically different central retinal artery normalized distance between ascending and descending limb of the wave (p = 0.016). Groups with different disease severity, classified following the Brusini glaucoma staging system 2, showed statistically different central retinal artery normalized distance between ascending and descending limb of the wave (p < 0.001) and central retinal artery period (p = 0.016). No statistical differences were found in regard to race, diabetes status, glaucoma family history, and smoking.
Ophthalmic artery and central retinal artery computer-aided analysis of velocity waveforms could identify novel waveform parameters capable of differentiating among different demographics and disease severity of open-angle glaucoma patients.
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Details
- Title
- Waveform parameters of retrobulbar vessels in glaucoma patients with different demographics and disease severity
- Creators
- Lucia Carichino - 1 Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA, USAAlon Harris - 2 Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, USASergey Lapin - 3 Department of Mathematics and Statistics, Washington State University, Pullman, WA, USAGiovanna Guidoboni - 4 Department of Electrical Engineering and Computer Science, University of Missouri, Columbia, MO, USASimone Cassani - 1 Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA, USAAnnalisa De Silvestri - 5 Clinical Epidemiology and Biometric Unit, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, ItalyCarmine Tinelli - 5 Clinical Epidemiology and Biometric Unit, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, ItalyGiovanni Milano - 6 University Eye Clinic, Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, ItalyBrent Siesky - 2 Department of Ophthalmology, Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, USAAlice C Verticchio Vercellin - 7 IRCCS Fondazione Bietti, Rome, Italy
- Publication Details
- European journal of ophthalmology, Vol.30(5), pp.1120672119848259-1027
- Academic Unit
- Mathematics and Statistics, Department of
- Publisher
- United States
- Identifiers
- 99900547768601842
- Language
- English
- Resource Type
- Journal article