Whisker stimulation increases expression of nerve growth factor- and interleukin-1β-immunoreactivity in the rat somatosensory cortex

Heather Hallett; Lynn Churchill; Ping Taishi; Alok De; James M Krueger

doi:10.1016/j.brainres.2010.03.048

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Whisker stimulation increases expression of nerve growth factor- and interleukin-1β-immunoreactivity in the rat somatosensory cortex

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Whisker stimulation increases expression of nerve growth factor- and interleukin-1β-immunoreactivity in the rat somatosensory cortex

Heather Hallett, Lynn Churchill, Ping Taishi, Alok De and James M Krueger

Brain research, Vol.1333, pp.48-56

2010

DOI: https://doi.org/10.1016/j.brainres.2010.03.048

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https://hdl.handle.net/2376/114211

PMCID: PMC2879054

PMID: 20338152

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https://doi.org/10.1016/j.brainres.2010.03.048View

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Abstract

Glial–neuronal interaction

Sleep

Astrocyte

Use-dependent

Cytokine

Activity-dependent changes in cortical protein expression may mediate long-term physiological processes such as sleep and neural connectivity. In this study we determined the number of nerve growth factor (NGF)- and interleukin-1β (IL1β)-immunoreactive (IR) cells in the somatosensory cortex (Sctx) in response to 2 h of mystacial whisker stimulation. Manual whisker stimulation for 2 h increased the number of NGF-IR cells within layers II-V in activated Sctx columns, identified by enhanced Fos-IR. IL1β-IR neurons increased within layers II-III and V-VI in these activated columns and IL1β-IR astrocytes increased in layers I, II-III and V as well as the external capsule beneath the activated columns. These whisker-stimulated increases in the Sctx did not occur in the auditory cortex. These data demonstrate that expression of NGF or IL1β in Sctx neurons and IL1β in Sctx astrocytes is, in part, afferent input-dependent.

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Title: Whisker stimulation increases expression of nerve growth factor- and interleukin-1β-immunoreactivity in the rat somatosensory cortex
Creators: Heather Hallett - Department of Veterinary & Comparative Anatomy, Pharmacology and Physiology, Sleep and Performance Research Center, Program in Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-6520, USA
Lynn Churchill - Department of Veterinary & Comparative Anatomy, Pharmacology and Physiology, Sleep and Performance Research Center, Program in Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-6520, USA
Ping Taishi - Department of Veterinary & Comparative Anatomy, Pharmacology and Physiology, Sleep and Performance Research Center, Program in Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-6520, USA
Alok De - Department of Veterinary & Comparative Anatomy, Pharmacology and Physiology, Sleep and Performance Research Center, Program in Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-6520, USA
James M Krueger - Department of Veterinary & Comparative Anatomy, Pharmacology and Physiology, Sleep and Performance Research Center, Program in Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-6520, USA
Publication Details: Brain research, Vol.1333, pp.48-56
Academic Unit: Integrative Physiology and Neuroscience, Department of
Publisher: Elsevier B.V
Identifiers: 99900547772601842
Language: English
Resource Type: Journal article