Journal article
Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project
Twin research and human genetics, Vol.18(5), pp.557-570
10/2015
Handle:
https://hdl.handle.net/2376/103838
PMCID: PMC4605819
PMID: 26337138
Abstract
A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.
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- Title
- Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project
- Creators
- Aline Jelenkovic - Department of Social Research, University of Helsinki, Helsinki, FinlandYoshie Yokoyama - Department of Public Health Nursing, Osaka City University, Osaka, JapanReijo Sund - Department of Social Research, University of Helsinki, Helsinki, FinlandChika Honda - Osaka University Graduate School of Medicine, Osaka University, Osaka, JapanLeonie H Bogl - Department of Public Health, University of Helsinki, Helsinki, FinlandSari Aaltonen - Department of Social Research, University of Helsinki, Helsinki, FinlandFuling Ji - Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, ChinaFeng Ning - Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, ChinaZengchang Pang - Department of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, ChinaJuan R Ordoñana - Department of Human Anatomy and Psychobiology, University of Murcia, Murcia, SpainJuan F Sánchez-Romera - Department of Developmental and Educational Psychology, University of Murcia, Murcia, SpainLucia Colodro-Conde - Department of Human Anatomy and Psychobiology, University of Murcia, Murcia, SpainS. Alexandra Burt - 1 Michigan State University, East Lansing, MI, USAKelly L Klump - 1 Michigan State University, East Lansing, MI, USASarah E Medland - 0 QIMR Berghofer Medical Research Institute, Brisbane, Queensland, AustraliaGrant W Montgomery - 0 QIMR Berghofer Medical Research Institute, Brisbane, Queensland, AustraliaChristian Kandler - 2 Department of Psychology, Bielefeld University, Bielefeld, GermanyTom A McAdams - 3 MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UKThalia C Eley - 3 MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UKAlice M Gregory - 4 Department of Psychology, Goldsmiths, University of London, New Cross, London, UKKimberly J Saudino - 5 Department of Psychological and Brain Sciencies, Boston University, Boston, MA, USALise Dubois - 6 School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Ontario, CanadaMichel Boivin - 7 École de psychologie, Université Laval, Québec, CanadaAdam D Tarnoki - 9 Department of Radiology and Oncotherapy, Semmelweis University, Budapest, HungaryDavid L Tarnoki - 9 Department of Radiology and Oncotherapy, Semmelweis University, Budapest, HungaryClaire M. A Haworth - 0 MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UKRobert Plomin - 3 MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UKSevgi Y Öncel - 1 Department of Statistics, Faculty of Arts and Sciences, Kırıkkale University, Kırıkkale, TurkeyFazil Aliev - 2 Departments of Psychiatry, Psychology, and Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USAMaria A Stazi - 4 Istituto Superiore di Sanità — National Center for Epidemiology, Surveillance and Health Promotion, Rome, ItalyCorrado Fagnani - 4 Istituto Superiore di Sanità — National Center for Epidemiology, Surveillance and Health Promotion, Rome, ItalyCristina D’Ippolito - 4 Istituto Superiore di Sanità — National Center for Epidemiology, Surveillance and Health Promotion, Rome, ItalyJeffrey M Craig - 5 Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Victoria, AustraliaRichard Saffery - 5 Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Victoria, AustraliaSisira H Siribaddana - 7 Institute of Research & Development, Battaramulla, Sri LankaMatthew Hotopf - 9 NIHR Mental Health Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, and Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UKAthula Sumathipala - 7 Institute of Research & Development, Battaramulla, Sri LankaFruhling Rijsdijk - 3 MRC Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UKTimothy Spector - 1 Department of Twin Research and Genetic Epidemiology, King's College London, London, UKMassimo Mangino - 1 Department of Twin Research and Genetic Epidemiology, King's College London, London, UKGenevieve Lachance - 1 Department of Twin Research and Genetic Epidemiology, King's College London, London, UKMargaret Gatz - 2 Department of Psychology, University of Southern California, Los Angeles, CA, USADavid A Butler - 4 Institute of Medicine, National Academy of Sciences Washington, DC, WA, USAGombojav Bayasgalan - 5 Healthy Twin Association of Mongolia, Ulaanbaatar, MongoliaDanshiitsoodol Narandalai - 6 Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanDuarte L Freitas - 7 Department of Physical Education and Sport, University of Madeira, Funchal, PortugalJosé Antonio Maia - 8 CIFI2D, Faculty of Sport, University of Porto, Porto, PortugalK. Paige Harden - 9 Department of Psychology, University of Texas at Austin, Austin, TX, USAElliot M Tucker-Drob - 9 Department of Psychology, University of Texas at Austin, Austin, TX, USABia Kim - 0 Department of Psychology, Pusan National University, Busan, South KoreaYoungsook Chong - 0 Department of Psychology, Pusan National University, Busan, South KoreaChanghee Hong - 0 Department of Psychology, Pusan National University, Busan, South KoreaHyun Jung Shin - 0 Department of Psychology, Pusan National University, Busan, South KoreaKaare Christensen - 1 The Danish Twin Registry, Institute of Public Health, Epidemiology, Biostatistics & Biodemography, University of Southern Denmark, Odense, DenmarkAxel Skytthe - 1 The Danish Twin Registry, Institute of Public Health, Epidemiology, Biostatistics & Biodemography, University of Southern Denmark, Odense, DenmarkKirsten O Kyvik - 3 Department of Clinical Research, University of Southern Denmark, Odense, DenmarkCatherine A Derom - 5 Centre of Human Genetics, University Hospitals Leuven, Leuven, BelgiumRobert F Vlietinck - 5 Centre of Human Genetics, University Hospitals Leuven, Leuven, BelgiumRuth J. F Loos - 6 The Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USAWendy Cozen - 7 Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USAAmie E Hwang - 7 Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USAThomas M Mack - 7 Department of Preventive Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USAMingguang He - 9 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, ChinaXiaohu Ding - 9 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, ChinaBilly Chang - 9 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, ChinaJudy L Silberg - 1 Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USALindon J Eaves - 1 Department of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USAHermine H Maes - 2 Department of Human and Molecular Genetics, Psychiatry & Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USATessa L Cutler - 3 The Australian Twin Registry, Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Victoria, AustraliaJohn L Hopper - 3 The Australian Twin Registry, Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Victoria, AustraliaKelly Aujard - 5 Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Victoria, AustraliaPatrik K. E Magnusson - 3 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenNancy L Pedersen - 3 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenAnna K. Dahl Aslan - 3 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenYun-Mi Song - 7 Department of Family Medicine, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South KoreaSarah Yang - 4 Department of Epidemiology, School of Public Health, Seoul National University, Seoul, South KoreaKayoung Lee - 9 Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, South KoreaLaura A Baker - 2 Department of Psychology, University of Southern California, Los Angeles, CA, USACatherine Tuvblad - 2 Department of Psychology, University of Southern California, Los Angeles, CA, USAMorten Bjerregaard-Andersen - 1 Bandim Health Project, INDEPTH Network, Bissau, Guinea-BissauHenning Beck-Nielsen - 3 Department of Endocrinology, Odense University Hospital, Odense, DenmarkMorten Sodemann - 4 Department of Infectious Diseases, Odense University Hospital, Odense, DenmarkKauko Heikkilä - Department of Public Health, University of Helsinki, Helsinki, FinlandQihua Tan - 5 Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, DenmarkDongfeng Zhang - 6 Department of Public Health, Qingdao University Medical College, Qingdao, ChinaGary E Swan - 7 Department of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USARuth Krasnow - 8 Center for Health Sciences, SRI International, Menlo Park, CA, USAKerry L Jang - 9 Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, CanadaAriel Knafo-Noam - 0 The Hebrew University of Jerusalem, Jerusalem, IsraelDavid Mankuta - 1 Department of Obstetrics and Gynecology, Hadassah Hospital, Hebrew University Medical School, Jerusalem, IsraelLior Abramson - 0 The Hebrew University of Jerusalem, Jerusalem, IsraelPaul Lichtenstein - 3 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenRobert F Krueger - 2 Department of Psychology, University of Minnesota, Minneapolis, MN, USAMatt McGue - 2 Department of Psychology, University of Minnesota, Minneapolis, MN, USAShandell Pahlen - 2 Department of Psychology, University of Minnesota, Minneapolis, MN, USAPer Tynelius - 3 Department of Public Health Sciences, Karolinska Institutet, Stockholm, SwedenGlen E Duncan - 4 Center for Clinical and Epidemiological Research, University of Washington, Seattle, WA, USADedra Buchwald - 4 Center for Clinical and Epidemiological Research, University of Washington, Seattle, WA, USARobin P Corley - 5 Institute for Behavioral Genetics, Boulder, CO, USABrooke M Huibregtse - 5 Institute for Behavioral Genetics, Boulder, CO, USATracy L Nelson - 6 Department of Health and Exercise Sciences and Colorado School of Public Health, Colorado State University, CO, USAKeith E Whitfield - 7 Psychology and Neuroscience, Duke University, Durham, NC, USACarol E Franz - 8 Department of Psychiatry, University of California, San Diego, CA, USAWilliam S Kremen - 8 Department of Psychiatry, University of California, San Diego, CA, USAMichael J Lyons - 0 Department of Psychology, Boston University, Boston, MA, USASyuichi Ooki - 1 Department of Health Science, Ishikawa Prefectural Nursing University, Kahoku, Ishikawa, JapanIngunn Brandt - 2 Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, NorwayThomas Sevenius Nilsen - 2 Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, NorwayFujio Inui - 3 Faculty of Health Science, Kio University, Nara, JapanMikio Watanabe - Osaka University Graduate School of Medicine, Osaka University, Osaka, JapanMeike Bartels - 4 Department of Biological Psychology, VU University Amsterdam, Amsterdam, The NetherlandsToos C. E. M van Beijsterveldt - 4 Department of Biological Psychology, VU University Amsterdam, Amsterdam, The NetherlandsJane Wardle - 5 Department of Epidemiology and Public Health, Health Behaviour Research Centre, Institute of Epidemiology and Health Care, University College London, London, UKClare H Llewellyn - 5 Department of Epidemiology and Public Health, Health Behaviour Research Centre, Institute of Epidemiology and Health Care, University College London, London, UKAbigail Fisher - 5 Department of Epidemiology and Public Health, Health Behaviour Research Centre, Institute of Epidemiology and Health Care, University College London, London, UKEsther Rebato - Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country UPV/EHU, Leioa, SpainNicholas G Martin - 0 QIMR Berghofer Medical Research Institute, Brisbane, Queensland, AustraliaYoshinori Iwatani - Osaka University Graduate School of Medicine, Osaka University, Osaka, JapanKazuo Hayakawa - Osaka University Graduate School of Medicine, Osaka University, Osaka, JapanJoohon Sung - 4 Department of Epidemiology, School of Public Health, Seoul National University, Seoul, South KoreaJennifer R Harris - 2 Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, NorwayGonneke Willemsen - 4 Department of Biological Psychology, VU University Amsterdam, Amsterdam, The NetherlandsAndreas Busjahn - 6 HealthTwiSt GmbH, Berlin, GermanyJack H Goldberg - 7 Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USAFinn Rasmussen - 3 Department of Public Health Sciences, Karolinska Institutet, Stockholm, SwedenYoon-Mi Hur - 8 Department of Education, Mokpo National University, Jeonnam, South KoreaDorret I Boomsma - 4 Department of Biological Psychology, VU University Amsterdam, Amsterdam, The NetherlandsThorkild I. A Sørensen - 9 Section on Metabolic Genetics, Novo Nordisk Foundation Centre for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkJaakko Kaprio - Department of Public Health, University of Helsinki, Helsinki, FinlandKarri Silventoinen - Department of Social Research, University of Helsinki, Helsinki, Finland
- Publication Details
- Twin research and human genetics, Vol.18(5), pp.557-570
- Academic Unit
- Community Health; Nutrition and Exercise Physiology, Department of
- Publisher
- Cambridge University Press; Cambridge, UK
- Number of pages
- 14
- Identifiers
- 99900546856901842
- Language
- English
- Resource Type
- Journal article