Journal article
dCREB2-Mediated Enhancement of Memory Formation
The Journal of neuroscience, Vol.33(17), pp.7475-7487
04/24/2013
Handle:
https://hdl.handle.net/2376/115652
PMCID: PMC3667961
PMID: 23616553
Abstract
CREB-responsive transcription has an important role in adaptive responses in all cells and tissue. In the nervous system, it has an essential and well established role in long-term memory formation throughout a diverse set of organisms. Activation of this transcription factor correlates with long-term memory formation and disruption of its activity interferes with this process. Most convincingly, augmenting CREB activity in a number of different systems enhances memory formation. In
Drosophila
, a sequence rearrangement in the original transgene used to enhance memory formation has been a source of confusion. This rearrangement prematurely terminates translation of the full-length protein, leaving the identity of the “enhancing molecule” unclear. In this report, we show that a naturally occurring, downstream, in-frame initiation codon is used to make a dCREB2 protein off of both transgenic and chromosomal substrates. This protein is a transcriptional activator and is responsible for memory enhancement. A number of parameters can affect enhancement, including the short-lived activity of the activator protein, and the time-of-day when induction and behavioral training occur. Our results reaffirm that overexpression of a dCREB2 activator can enhance memory formation and illustrate the complexity of this behavioral enhancement.
Metrics
6 Record Views
Details
- Title
- dCREB2-Mediated Enhancement of Memory Formation
- Creators
- Thomas C Tubon - Departments of Genetics andJiabin Zhang - Departments of Genetics andEugenia L Friedman - Departments of Genetics andHaining Jin - Department of Human Oncology, Wisconsin Institute of Medical ResearchErin D Gonzales - Departments of Genetics andHong Zhou - Departments of Genetics andDiana Drier - Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin 53706Jason R Gerstner - Center for Sleep, University of Pennsylvania, Philadelphia, Pennsylvania 19104Emily A Paulson - Departments of Genetics andRobin Fropf - Departments of Genetics andJerry C. P Yin - Departments of Genetics and
- Publication Details
- The Journal of neuroscience, Vol.33(17), pp.7475-7487
- Academic Unit
- Biomedical Sciences, Department of; Pharmaceutical Sciences, Department of
- Publisher
- Society for Neuroscience
- Identifiers
- 99900547624401842
- Language
- English
- Resource Type
- Journal article