Journal article
pH-Controlled Hydrogen Sulfide Release for Myocardial Ischemia-Reperfusion Injury
Journal of the American Chemical Society, Vol.138(20), pp.6336-6339
05/25/2016
Handle:
https://hdl.handle.net/2376/101887
PMID: 27172143
Abstract
Hydrogen sulfide (H2S) is a critical signaling molecule that regulates many physiological and/or pathological processes. Modulation of H2S levels could have potential therapeutic value. In this work, we report the rational design, synthesis, and biological evaluation of a class of phosphonamidothioate-based H2S-releasing agents (i.e., H2S donors). A novel pH-dependent intramolecular cyclization was employed to promote H2S release from the donors. These water-soluble compounds showed slow, controllable, and pH-sensitive production of H2S in aqueous solutions. The donors also showed significant cytoprotective effects in cellular models of oxidative damage. Most importantly, the donors were found to exhibit potent cardioprotective effects in an in vivo murine model of myocardial ischemia-reperfusion (MI/R) injury through a H2S-related mechanism.
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Details
- Title
- pH-Controlled Hydrogen Sulfide Release for Myocardial Ischemia-Reperfusion Injury
- Creators
- Jianming Kang - Department of Chemistry, Washington State University , Pullman, Washington 99164, United StatesZhen Li - Cardiovascular Center of Excellence, Louisiana State University Health Science Center , New Orleans, Louisiana 70112, United StatesChelsea L Organ - Cardiovascular Center of Excellence, Louisiana State University Health Science Center , New Orleans, Louisiana 70112, United StatesChung-Min Park - Department of Chemistry, Gangneung-Wonju National University , Gangneung, Gangwon 25457, South KoreaChun-Tao Yang - Department of Physiology, Guangzhou Medical University , Guangzhou 511436, ChinaArmando Pacheco - Department of Chemistry, Washington State University , Pullman, Washington 99164, United StatesDifei Wang - Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center , Washington, D.C. 20057, United StatesDavid J Lefer - Cardiovascular Center of Excellence, Louisiana State University Health Science Center , New Orleans, Louisiana 70112, United StatesMing Xian - Department of Chemistry, Washington State University , Pullman, Washington 99164, United States
- Publication Details
- Journal of the American Chemical Society, Vol.138(20), pp.6336-6339
- Academic Unit
- Chemistry, Department of
- Publisher
- United States
- Identifiers
- 99900546549901842
- Language
- English
- Resource Type
- Journal article