Journal article
pH-Sensitive ZnO Quantum Dots-Doxorubicin Nanoparticles for Lung Cancer Targeted Drug Delivery
ACS applied materials & interfaces, Vol.8(34), pp.22442-22450
08/31/2016
PMID: 27463610
Abstract
In this paper, we reported a ZnO quantum dots-based pH-responsive drug delivery platform for intracellular controlled release of drugs. Acid-decomposable, luminescent aminated ZnO quantum dots (QDs) were synthesized as nanocarriers with ultrasmall size (similar to 3 nm). The dicarboxyl-terminated poly(ethylene glycol) (PEG) had been introduced to NH2-ZnO QDs, which rendered it stable under physiological fluid. Moreover, a targeting ligand, hyaluronic acid (HA), was conjugated to ZnO QDs for specifically binding to the overexpressed glycoprotein CD44 by cancer cells. Doxorubicin (DOX) molecules were successfully loaded to PEG functionalized ZnO QDs via formation of metal DOX complex and covalent interactions. The pH-sensitive ZnO QDs dissolved to Zn2+ in acidic endosome/lysosome after uptake by cancer cells, which triggered dissociation of the metal-drug complex and a controlled DOX release. As result, a synergistic therapy was achieved due to incorporation of the antitumor effect of Zn2+ and DOX.
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Details
- Title
- pH-Sensitive ZnO Quantum Dots-Doxorubicin Nanoparticles for Lung Cancer Targeted Drug Delivery
- Creators
- Xiaoli Cai - Central China Normal UniversityYanan Luo - Washington State UniversityWeiying Zhang - Jianghan UniversityDan Du - Washington State UniversityYuehe Lin - Central China Normal University
- Publication Details
- ACS applied materials & interfaces, Vol.8(34), pp.22442-22450
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- Amer Chemical Soc
- Number of pages
- 9
- Grant note
- 21575047; 21275062 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) WSU
- Identifiers
- 99901227851001842
- Language
- English
- Resource Type
- Journal article