Preprint
Circadian Control of Pulmonary Endothelial Signaling occurs via the NADPH oxidase 2-NLRP3 pathway
bioRxiv
06/2022
Abstract
Circadian rhythms are endogenous oscillations that occur with a 24-hr periodicity. These rhythms are ubiquitous and thus, vascular endothelial cells that line the vascular bed are also subjected to circadian regulation. While the circadian control of vascular function has been demonstrated in the context of various pathologies, the relevance and functional implication of clock control over pulmonary vasculature has never been investigated. As the pulmonary endothelium is a crucial site for the host’s inflammatory response to a lung specific pathogen, we investigated the role of the circadian clock in mediation the response of the pulmonary endothelium to inflammation. We hypothesized that the pulmonary endothelium is under circadian control and that the clock serves to curb inflammatory signaling.
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Details
- Title
- Circadian Control of Pulmonary Endothelial Signaling occurs via the NADPH oxidase 2-NLRP3 pathway
- Creators
- Shaon Sengupta (Author) - Children's Hospital of PhiladelphiaYool Lee (Author) - Washington State University, Biomedical Sciences, Department ofJian Qin Tao (Author) - University of PennsylvaniaAmita Sehgal (Author) - University of PennsylvaniaShampa Chatterjee (Author) - University of Pennsylvania
- Academic Unit
- Elson S. Floyd College of Medicine
- Publisher
- bioRxiv
- Identifiers
- 99901132541301842
- Copyright
- The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
- Language
- English
- Resource Type
- Preprint